Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling

• Main Author: Le, Thi Thu Huong
• Format: Article
• Language: English
• Published: Springer 2016
• Subjects: ADME modeling; Caco-2 cell permeability; Biopharmaceutics classification system; Support vector machine; Cost-sensitive learning; Resampling technique
• Online Access: http://repository.vnu.edu.vn/handle/VNU_123/11505
• Institution: Vietnam National University, Hanoi

In many absorption, distribution, metabolism, and excretion (ADME) modeling problems, imbalanced data could negatively affect classification performance of machine learning algorithms. Solutions for handling imbal-anced dataset have been proposed, but their application for ADME modeling tasks is...