Towards Better BBB Passage Prediction Using an Extensive and Curated Data Set

• 主要作者: Le, Thi Thu Huong
• 格式: Article
• 語言: English
• 出版: Wiley 2016
• 主題: Linear discriminant analysis; Multiple linear regression relationship; · Blood brain barrier; BBB endpoint; Dragon descriptor
• 在線閱讀: http://repository.vnu.edu.vn/handle/VNU_123/11508

In the present report, the challenging task of drug delivery across the blood-brain barrier (BBB) is ad-dressed via a computational approach. The BBB passage was modeled using classification and regression schemes on a novel extensive and curated data set (the largest to the best of our knowledg...