Targeted Therapies in Cancer

Cancers share a restricted set of characteristics crucial to the tumor phenotype: proliferation in the absence of external growth stimuli, avoidance of apoptosis and no limits to replication, escape from external growth-suppressive forces and the immune response, an inflammatory micro-environment wi...

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Other Authors: Colotta, Francesco
Format: Book
Language:English
Published: Springer 2017
Subjects:
616
Online Access:http://repository.vnu.edu.vn/handle/VNU_123/26443
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Institution: Vietnam National University, Hanoi
Language: English
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spelling oai:112.137.131.14:VNU_123-264432020-07-10T01:43:09Z Targeted Therapies in Cancer Colotta, Francesco Mantovani, Alberto Biomedical Sciences Cancer Research 616 Cancers share a restricted set of characteristics crucial to the tumor phenotype: proliferation in the absence of external growth stimuli, avoidance of apoptosis and no limits to replication, escape from external growth-suppressive forces and the immune response, an inflammatory micro-environment with new blood vessel formation, and an ability to invade normal tissues. In the last 20 years, the molecular determinants of these behaviors are becoming increasingly well understood. This has changed the current paradigm underlying the drug discovery process intended to identify novel therapies to fight cancer.In the past most efforts to identify novel therapies to cancer were focused on the empirical observation of natural or chemically synthesized molecules that inhibited cancer cell growth in vitro and/or in vivo. Most often, the molecular mechanisms underlying the observed anti-cancer activities of empirically discovered anti-cancer agents were discovered afterwards. Cornerstones of currently used chemotherapeutic armamentarium have been discovered according to this “ empiricism-based paradigm.” 2017-04-12T01:29:03Z 2017-04-12T01:29:03Z 2008 Book 978-0-387-73897-0 http://repository.vnu.edu.vn/handle/VNU_123/26443 en 200 p. application/pdf Springer
institution Vietnam National University, Hanoi
building VNU Library & Information Center
country Vietnam
collection VNU Digital Repository
language English
topic Biomedical Sciences
Cancer Research
616
spellingShingle Biomedical Sciences
Cancer Research
616
Targeted Therapies in Cancer
description Cancers share a restricted set of characteristics crucial to the tumor phenotype: proliferation in the absence of external growth stimuli, avoidance of apoptosis and no limits to replication, escape from external growth-suppressive forces and the immune response, an inflammatory micro-environment with new blood vessel formation, and an ability to invade normal tissues. In the last 20 years, the molecular determinants of these behaviors are becoming increasingly well understood. This has changed the current paradigm underlying the drug discovery process intended to identify novel therapies to fight cancer.In the past most efforts to identify novel therapies to cancer were focused on the empirical observation of natural or chemically synthesized molecules that inhibited cancer cell growth in vitro and/or in vivo. Most often, the molecular mechanisms underlying the observed anti-cancer activities of empirically discovered anti-cancer agents were discovered afterwards. Cornerstones of currently used chemotherapeutic armamentarium have been discovered according to this “ empiricism-based paradigm.”
author2 Colotta, Francesco
author_facet Colotta, Francesco
format Book
title Targeted Therapies in Cancer
title_short Targeted Therapies in Cancer
title_full Targeted Therapies in Cancer
title_fullStr Targeted Therapies in Cancer
title_full_unstemmed Targeted Therapies in Cancer
title_sort targeted therapies in cancer
publisher Springer
publishDate 2017
url http://repository.vnu.edu.vn/handle/VNU_123/26443
_version_ 1680964905871605760