Regulatory T Cells and Clinical Application

Regulatory T-cell population is now widely accepted as an important component of the immune system as professional suppressors of immune responses. It was shown in the late sixties that some CD4+ T cells in normal mice were capable of suppressing autoimmunity. Efforts to characterize this autoimmun...

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Other Authors: Jiang, Shuiping
Format: Book
Language:English
Published: Springer 2017
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Online Access:http://repository.vnu.edu.vn/handle/VNU_123/32665
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Institution: Vietnam National University, Hanoi
Language: English
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spelling oai:112.137.131.14:VNU_123-326652020-05-13T01:41:32Z Regulatory T Cells and Clinical Application Jiang, Shuiping Biomedical and Life Sciences Regulatory T-cell population is now widely accepted as an important component of the immune system as professional suppressors of immune responses. It was shown in the late sixties that some CD4+ T cells in normal mice were capable of suppressing autoimmunity. Efforts to characterize this autoimmune-suppressive CD4+ T cell population led to the identification of CD25 as a constitutional marker. Using this marker, it became possible to separate regulatory T cells from other CD4+ T cells, to further analyze their developmental pathways, especially in the thymus, and to better describe how they suppress immune responses in vivo and in vitro. The marker was also found to be useful to identify regulatory T cells with comparable suppressive function and phenotype in humans. It was recently shown that transcription factor Foxp3 was specifically expressed by CD25+ CD4+ regulatory T cells in rodents. Anomalies in FOXP3 gene are responsible for the development of an autoimmune and inflammatory disease in humans and rodents characterized by a deficiency in the development and function of CD25+CD4+ regulatory T cells. These recent findings provide clear evidence that Foxp3+CD25+CD4+ regulatory T cells are indispensable for the establishment and the maintenance of immunologic self-tolerance and immune homeostasis. Therefore, characterization of regulatory T cell mediated immune suppression should bring new clinical tools to control pathological immune responses. 2017-04-25T03:10:30Z 2017-04-25T03:10:30Z 2009 Book 9780387779089 http://repository.vnu.edu.vn/handle/VNU_123/32665 en application/pdf Springer
institution Vietnam National University, Hanoi
building VNU Library & Information Center
country Vietnam
collection VNU Digital Repository
language English
topic Biomedical and Life Sciences
spellingShingle Biomedical and Life Sciences
Regulatory T Cells and Clinical Application
description Regulatory T-cell population is now widely accepted as an important component of the immune system as professional suppressors of immune responses. It was shown in the late sixties that some CD4+ T cells in normal mice were capable of suppressing autoimmunity. Efforts to characterize this autoimmune-suppressive CD4+ T cell population led to the identification of CD25 as a constitutional marker. Using this marker, it became possible to separate regulatory T cells from other CD4+ T cells, to further analyze their developmental pathways, especially in the thymus, and to better describe how they suppress immune responses in vivo and in vitro. The marker was also found to be useful to identify regulatory T cells with comparable suppressive function and phenotype in humans. It was recently shown that transcription factor Foxp3 was specifically expressed by CD25+ CD4+ regulatory T cells in rodents. Anomalies in FOXP3 gene are responsible for the development of an autoimmune and inflammatory disease in humans and rodents characterized by a deficiency in the development and function of CD25+CD4+ regulatory T cells. These recent findings provide clear evidence that Foxp3+CD25+CD4+ regulatory T cells are indispensable for the establishment and the maintenance of immunologic self-tolerance and immune homeostasis. Therefore, characterization of regulatory T cell mediated immune suppression should bring new clinical tools to control pathological immune responses.
author2 Jiang, Shuiping
author_facet Jiang, Shuiping
format Book
title Regulatory T Cells and Clinical Application
title_short Regulatory T Cells and Clinical Application
title_full Regulatory T Cells and Clinical Application
title_fullStr Regulatory T Cells and Clinical Application
title_full_unstemmed Regulatory T Cells and Clinical Application
title_sort regulatory t cells and clinical application
publisher Springer
publishDate 2017
url http://repository.vnu.edu.vn/handle/VNU_123/32665
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