pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels
p. 45-50
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2017
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oai:112.137.131.14:VNU_123-581612017-09-30T20:28:29Z pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels Dwivedi, Raman Singh, Alok Kumar Dhillon, Anju pH Drug release Kinetics Hydrogel Diffusion p. 45-50 A study of pH responsive drug release from dependal-M drug loaded polyacrylamide (PAM) hydrogel matrix is reported. PAM hydrogel with different crosslinker concentrations has been taken for the different drug loading capacities. The associative interaction of drug in the polymer network complicates the release pattern of drug, and the release kinetics show a dependence on the cross linker and its ratio. The drug release kinetics in hydrogel with higher cross linker (H1) and less crosslinked hydrogel (H2) are followed by the Higuchi's model and the KorsmeyerePeppas model, respectively. Drug release mecha-nism is based on diffusion. Initial burst of drug release was observed at pH 5.8. The calculated diffusion coefficient (D) is 2.57 for H1 and 1.799 for H2 2017-08-24T03:08:45Z 2017-08-24T03:08:45Z 2017 Article 2468-2284 http://repository.vnu.edu.vn/handle/VNU_123/58161 other application/pdf H. : ĐHQGHN |
| institution |
Vietnam National University, Hanoi |
| building |
VNU Library & Information Center |
| country |
Vietnam |
| collection |
VNU Digital Repository |
| language |
other |
| topic |
pH Drug release Kinetics Hydrogel Diffusion |
| spellingShingle |
pH Drug release Kinetics Hydrogel Diffusion Dwivedi, Raman Singh, Alok Kumar Dhillon, Anju pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels |
| description |
p. 45-50 |
| format |
Article |
| author |
Dwivedi, Raman Singh, Alok Kumar Dhillon, Anju |
| author_facet |
Dwivedi, Raman Singh, Alok Kumar Dhillon, Anju |
| author_sort |
Dwivedi, Raman |
| title |
pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels |
| title_short |
pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels |
| title_full |
pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels |
| title_fullStr |
pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels |
| title_full_unstemmed |
pH-responsive drug release from dependal-M loaded polyacrylamide hydrogels |
| title_sort |
ph-responsive drug release from dependal-m loaded polyacrylamide hydrogels |
| publisher |
H. : ĐHQGHN |
| publishDate |
2017 |
| url |
http://repository.vnu.edu.vn/handle/VNU_123/58161 |
| _version_ |
1680964150373646336 |