The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro

p. 482-487

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Main Authors: Jussi Sarin, Leena Bjorkvik, Markus Hiltunen, Leena Hupa, Jaakko Pulkkinen, Pekka K. Vallittu
Format: Article
Language:English
Published: ĐHQGHN 2017
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Online Access:http://repository.vnu.edu.vn/handle/VNU_123/58303
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Institution: Vietnam National University, Hanoi
Language: English
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spelling oai:112.137.131.14:VNU_123-583032017-09-30T20:48:55Z The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro Jussi Sarin Leena Bjorkvik Markus Hiltunen Leena Hupa Jaakko Pulkkinen Pekka K. Vallittu Bioactive glass S53P4 Fibrin sealant Fibrin glue p. 482-487 Fibrin glue, a two-component tissue adhesive, has a range of clinical indications. Bioactive glass (BG) S53P4 has been approved for clinical use in several craniomaxillofacial and orthopedic applications. Although sometimes used simultaneously, there is no data available regarding the possible interaction of these two biocompatible substances. In this in vitro study, using a BG particle concentration of 4 mg/ml, a 0.4 unit pH increment (p < 0.001) was observed in simulated body fluid (SBF) after a 7-day incubation period. The addition of fibrin glue (0.13 g, SD 0.04; or 3.7 mg/ml) on top of the BG particles raised further the pH by 0.5 units (p < 0.001). The difference between these groups was statistically significant (p = 0.008). With a BG concentration of 25 mg/ml and a fibrin glue concentration of 18 mg/ml during a 14-day incubation period, a pH increment of 0.6 units and SBF ion concentration change of Ca, K, Mg, Na, P and Si ions was seen. Moreover, a penetration depth between 4 and 6 mm was observed when fibrin glue was applied on top of a bed of BG particles. Conclusions: Fibrin glue is not likely to have a distracting effect on BG-induced pH increase of the SBF although it might delay early BG surface reactions based on ion concentration measurements. Fibrin glue penetrated to the interparticle space to some extent, binding the particles together for easy clinical use of BG. 2017-08-24T09:18:00Z 2017-08-24T09:18:00Z 2016 Article 2468-2284 http://repository.vnu.edu.vn/handle/VNU_123/58303 en application/pdf ĐHQGHN
institution Vietnam National University, Hanoi
building VNU Library & Information Center
country Vietnam
collection VNU Digital Repository
language English
topic Bioactive glass
S53P4
Fibrin sealant
Fibrin glue
spellingShingle Bioactive glass
S53P4
Fibrin sealant
Fibrin glue
Jussi Sarin
Leena Bjorkvik
Markus Hiltunen
Leena Hupa
Jaakko Pulkkinen
Pekka K. Vallittu
The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
description p. 482-487
format Article
author Jussi Sarin
Leena Bjorkvik
Markus Hiltunen
Leena Hupa
Jaakko Pulkkinen
Pekka K. Vallittu
author_facet Jussi Sarin
Leena Bjorkvik
Markus Hiltunen
Leena Hupa
Jaakko Pulkkinen
Pekka K. Vallittu
author_sort Jussi Sarin
title The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
title_short The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
title_full The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
title_fullStr The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
title_full_unstemmed The effect of fibrin sealant on bioactive glass S53P4 particles - pH impact and dissolution characteristics in vitro
title_sort effect of fibrin sealant on bioactive glass s53p4 particles - ph impact and dissolution characteristics in vitro
publisher ĐHQGHN
publishDate 2017
url http://repository.vnu.edu.vn/handle/VNU_123/58303
_version_ 1680966984634728448