Establishing the Genotyping Method for NAT2 Polymorphism in Vietnamese Tuberculoma Patients

• Main Authors: Pham, Thi Hong Nhung, Kieu, Hong Nhung, Dinh, Doan Long, Vu, Thi Thom, Le, Thi Luyen, Nguyen, Thi Thu Ha
• Format: Article
• Language: Vietnamese
• Published: H. : ĐHQGHN 2019
• Subjects: Enzyme NAT2; Isoniazid; Single nucleotide polymorphism; RFLP; Sanger sequencing
• Online Access: http://repository.vnu.edu.vn/handle/VNU_123/64813; https://doi.org/10.25073/2588-1132/vnumps.4137
• Institution: Vietnam National University, Hanoi

The metabolism of Isoniazid, one of the first-line antituberculosis drugs for TB treatment and prophylaxis, depends on the acetyltransferase 2 acetylation (NAT2) phenotype. Different phenotypes of NAT2 will lead to differences in drug concentration and the risk of uncontrolled side effects, such as...