All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45

Cellular senescence is a state in wich cells can not longer divide. The dysregulation of the cell senescence signaling pathway could lead to uncontrolled cell proliferation and formation of malignant cells. Intervening in cell senessence signaling pathway to bring cancer cells back to cell senessenc...

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Main Authors: Luu, Thi Binh, Le, Thi Thanh Huong, Nguyen, Trung Thanh, Nguyen, Phu Hung
Format: Article
Language:English
Published: H. : ĐHQGHN 2020
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Online Access:http://repository.vnu.edu.vn/handle/VNU_123/68388
https://doi.org/10.25073/2588-1140/vnunst.4907
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Institution: Vietnam National University, Hanoi
Language: English
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spelling oai:112.137.131.14:VNU_123-683882020-01-07T08:31:19Z All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45 Luu, Thi Binh Le, Thi Thanh Huong Nguyen, Trung Thanh Nguyen, Phu Hung All trans retinoic acid Gastric cancer stem cell Cell senescence Cellular senescence is a state in wich cells can not longer divide. The dysregulation of the cell senescence signaling pathway could lead to uncontrolled cell proliferation and formation of malignant cells. Intervening in cell senessence signaling pathway to bring cancer cells back to cell senessence state is a potential way in cancertreatment. Recent studies show that tumor cells can undergo celluar senessencestate by using special chemotherapy. In this study, we indicatedthat All trans retinoic acid (ATRA) is able to influence the expression of genes involved in cell senessence signaling pathway in gastric cancer cells MKN45. ATRA down-regulatesthe expression of important genes controlling cell growth. On the other hand, ATRA up-regulate the expression of GADD45A, P21 and P53 genes that play an important role in the signaling pathway of cells.This finding suggestes that ATRA could inhibite MKN45 cells through activating cell senescence signaling pathway 2020-01-07T08:31:19Z 2020-01-07T08:31:19Z 2019 Article Luu, T. B., et al. (2019). All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45. VNU Journal of Science: Natural Sciences and Technology, Vol. 35, No. 4 (2019) 29-36 2588-1140 http://repository.vnu.edu.vn/handle/VNU_123/68388 https://doi.org/10.25073/2588-1140/vnunst.4907 en VNU Journal of Science: Natural Sciences and Technology; application/pdf H. : ĐHQGHN
institution Vietnam National University, Hanoi
building VNU Library & Information Center
country Vietnam
collection VNU Digital Repository
language English
topic All trans retinoic acid
Gastric cancer stem cell
Cell senescence
spellingShingle All trans retinoic acid
Gastric cancer stem cell
Cell senescence
Luu, Thi Binh
Le, Thi Thanh Huong
Nguyen, Trung Thanh
Nguyen, Phu Hung
All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45
description Cellular senescence is a state in wich cells can not longer divide. The dysregulation of the cell senescence signaling pathway could lead to uncontrolled cell proliferation and formation of malignant cells. Intervening in cell senessence signaling pathway to bring cancer cells back to cell senessence state is a potential way in cancertreatment. Recent studies show that tumor cells can undergo celluar senessencestate by using special chemotherapy. In this study, we indicatedthat All trans retinoic acid (ATRA) is able to influence the expression of genes involved in cell senessence signaling pathway in gastric cancer cells MKN45. ATRA down-regulatesthe expression of important genes controlling cell growth. On the other hand, ATRA up-regulate the expression of GADD45A, P21 and P53 genes that play an important role in the signaling pathway of cells.This finding suggestes that ATRA could inhibite MKN45 cells through activating cell senescence signaling pathway
format Article
author Luu, Thi Binh
Le, Thi Thanh Huong
Nguyen, Trung Thanh
Nguyen, Phu Hung
author_facet Luu, Thi Binh
Le, Thi Thanh Huong
Nguyen, Trung Thanh
Nguyen, Phu Hung
author_sort Luu, Thi Binh
title All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45
title_short All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45
title_full All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45
title_fullStr All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45
title_full_unstemmed All Trans Retinoic Acid Regulates Expression of Genes Invoved in Cell Senescence Pathway in Gastric Cancer Cell Line MKN45
title_sort all trans retinoic acid regulates expression of genes invoved in cell senescence pathway in gastric cancer cell line mkn45
publisher H. : ĐHQGHN
publishDate 2020
url http://repository.vnu.edu.vn/handle/VNU_123/68388
https://doi.org/10.25073/2588-1140/vnunst.4907
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