Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract

Rutin is a natural flavonoid that has many effects on human health and beauty. However, rutin has low solubility and bioavailability. Niosomes are drug delivery system that enhance drug permeation of drug through the skin. Aloe is widly used in cosmetic preparations due to its antiaging, moisturizin...

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Main Authors: Tran, Thi Hai Yen, Hoang, Thi Hien, Vu, Thi Thu Giang
Format: Article
Language:English
Published: H. : ĐHQGHN 2020
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Online Access:http://repository.vnu.edu.vn/handle/VNU_123/74886
https://doi.org/10.25073/2588-1132/vnumps.4208
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Institution: Vietnam National University, Hanoi
Language: English
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spelling oai:112.137.131.14:VNU_123-748862020-04-01T02:51:40Z Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract Tran, Thi Hai Yen Hoang, Thi Hien Vu, Thi Thu Giang Rutin Aloe Niosomes Nano Entrapment efficiency Drug loading Rutin is a natural flavonoid that has many effects on human health and beauty. However, rutin has low solubility and bioavailability. Niosomes are drug delivery system that enhance drug permeation of drug through the skin. Aloe is widly used in cosmetic preparations due to its antiaging, moisturizing and essential skin nutrients. Therefore, the aim of study is preparation of nano niosomes, loaded with rutin and aloe gel extraction (rutin-aloe niosomes) by thin film hydration method. Rutin niosomes was reduced size by ultrasonic method. The size and distribution of vesicles were determined by dynamic light scattering method. Drug content in niosomal suspension was determined by UV-Vis absorption spectroscopy. The results showed that rutin-aloe niosomes were prepared by thin-film hydration method using Span 60, cholesterol and rutin in molar ratio of 7:3:4 using aloe gel extract as hydration solvent. Mixture of methanol-chloroform (volume ratio 1:1) was used as solvent for solution of membrane companents for evaporation. The manufactured rutinaloe niosomes had size of about 160 nm, the entrapment efficiency was 95,57% and drug loading was 32,06%. 2020-04-01T02:51:40Z 2020-04-01T02:51:40Z 2020 Article Tran, T. H. Y., Hoang, T. H., Vu, T. T. G. (2020). Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract. VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 36, No. 1 (2020) 46-54 http://repository.vnu.edu.vn/handle/VNU_123/74886 https://doi.org/10.25073/2588-1132/vnumps.4208 en application/pdf H. : ĐHQGHN
institution Vietnam National University, Hanoi
building VNU Library & Information Center
country Vietnam
collection VNU Digital Repository
language English
topic Rutin
Aloe
Niosomes
Nano
Entrapment efficiency
Drug loading
spellingShingle Rutin
Aloe
Niosomes
Nano
Entrapment efficiency
Drug loading
Tran, Thi Hai Yen
Hoang, Thi Hien
Vu, Thi Thu Giang
Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
description Rutin is a natural flavonoid that has many effects on human health and beauty. However, rutin has low solubility and bioavailability. Niosomes are drug delivery system that enhance drug permeation of drug through the skin. Aloe is widly used in cosmetic preparations due to its antiaging, moisturizing and essential skin nutrients. Therefore, the aim of study is preparation of nano niosomes, loaded with rutin and aloe gel extraction (rutin-aloe niosomes) by thin film hydration method. Rutin niosomes was reduced size by ultrasonic method. The size and distribution of vesicles were determined by dynamic light scattering method. Drug content in niosomal suspension was determined by UV-Vis absorption spectroscopy. The results showed that rutin-aloe niosomes were prepared by thin-film hydration method using Span 60, cholesterol and rutin in molar ratio of 7:3:4 using aloe gel extract as hydration solvent. Mixture of methanol-chloroform (volume ratio 1:1) was used as solvent for solution of membrane companents for evaporation. The manufactured rutinaloe niosomes had size of about 160 nm, the entrapment efficiency was 95,57% and drug loading was 32,06%.
format Article
author Tran, Thi Hai Yen
Hoang, Thi Hien
Vu, Thi Thu Giang
author_facet Tran, Thi Hai Yen
Hoang, Thi Hien
Vu, Thi Thu Giang
author_sort Tran, Thi Hai Yen
title Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
title_short Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
title_full Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
title_fullStr Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
title_full_unstemmed Preparation of Nano Niosomes Loaded with Rutin and Aloe Gel Extract
title_sort preparation of nano niosomes loaded with rutin and aloe gel extract
publisher H. : ĐHQGHN
publishDate 2020
url http://repository.vnu.edu.vn/handle/VNU_123/74886
https://doi.org/10.25073/2588-1132/vnumps.4208
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