DJ-1/PARK7 protein : Parkinson's disease, cancer and oxidative stress-induced diseases

• مؤلفون آخرون: Ariga, Hiroyoshi ; Iguchi-Ariga, Sanae M. M.
• التنسيق: كتاب
• اللغة: English
• منشور في: Springer 2020
• الموضوعات: Proteins ; Nervous system ; Degeneration ; Molecular aspects ; Cancer ; Hệ thần kinh > Thoái hóa > Khía cạnh phân tử ; Ung thư; 572.6 DJP 2017
• الوصول للمادة أونلاين: http://repository.vnu.edu.vn/handle/VNU_123/90742

Introduction/overview -- Structural biology of the DJ-1 superfamily -- Expression of DJ-1 in patients with neurodegenerative diseases -- DJ-1 as an oncogene and its clinical significance -- Role of DJ-1 in fertilization -- Anti-oxidative stress function of DJ-1 -- Transcriptional regulation of DJ-1 -- Regulation of signal transduction by DJ-1 -- Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal -- DJ-1 as a biomarker of Parkinson's disease -- Roles of DJ-1 in diabetes mellitus -- Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases -- DJ-1 as an oncogene and promising target for cancer chemotherapy.