Proteases in physiology and pathology

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors....

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Other Authors: Chakraborti, Sajal ; Dhalla, Naranjan S.
Format: Book
Language:English
Published: Springer 2020
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Online Access:http://repository.vnu.edu.vn/handle/VNU_123/90765
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Institution: Vietnam National University, Hanoi
Language: English
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spelling oai:112.137.131.14:VNU_123-907652020-11-05T02:28:01Z Proteases in physiology and pathology Chakraborti, Sajal ; Dhalla, Naranjan S. Proteolytic enzymes ; Phân giải enzymes 572 PRO 2017 Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field. 2020-08-26T08:02:18Z 2020-08-26T08:02:18Z 2017 Book 9789811025136 http://repository.vnu.edu.vn/handle/VNU_123/90765 en © Springer Nature Singapore Pte Ltd. 2017 619 p. application/pdf Springer
institution Vietnam National University, Hanoi
building VNU Library & Information Center
continent Asia
country Vietnam
Vietnam
content_provider VNU Library and Information Center
collection VNU Digital Repository
language English
topic Proteolytic enzymes ; Phân giải enzymes
572 PRO 2017
spellingShingle Proteolytic enzymes ; Phân giải enzymes
572 PRO 2017
Proteases in physiology and pathology
description Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.
author2 Chakraborti, Sajal ; Dhalla, Naranjan S.
author_facet Chakraborti, Sajal ; Dhalla, Naranjan S.
format Book
title Proteases in physiology and pathology
title_short Proteases in physiology and pathology
title_full Proteases in physiology and pathology
title_fullStr Proteases in physiology and pathology
title_full_unstemmed Proteases in physiology and pathology
title_sort proteases in physiology and pathology
publisher Springer
publishDate 2020
url http://repository.vnu.edu.vn/handle/VNU_123/90765
_version_ 1683409501123772416