Antimicrobial activities of terpenoid compounds and derivatives from Ardisia Swartz, Syzygium samarangense and Cinnamomum cebuense

• Main Authors: Ocampo, Shelly Anne, Carranza, Sophia Loren, Rodriguez, Ma. Dominique
• Format: text
• Language: English
• Published: Animo Repository 2011
• Subjects: Antineoplastic agents; Staphylococcus aureus infections; Biology
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/10506
• Institution: De La Salle University

The study aimed to evaluate the anti-microbial potential of the compounds, terpenes present in Ardisia Swartz, Syzygium samarangense and Cinnamomum cebuense. Terpenes comprise a diverse group of plant compounds in many plant species. Extracts obtained from the plant of Ardisia Swartz, leaves of Syzygium samarangense and bark of Cinnamomum cebuense were tested on gram-positive Bacillus subtilis, methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), gram-negative Escherichia coli and Klebsiella pneumoniae and fungus Candida albicans by well diffusion method on a Mueller-Hinton agar (MHA). The extracts from Ardisia sp. (ASP16) and Cinnamommum cebuense (CB1) showed antibacterial activity against MRSA, MSSA and B. subtilis. The compound ASP16 inhibited B. subtilis, MSSA and MRSA with the highest mean diameter zone of inhibition of 10.00, 14.33 and 20.67mm respectively, at a concentration of 500og/ol, while CB1 inhibited B. subtilis and MRSA with the highest mean diameter zone of inhibition of 11.33 and 14.00mm among the five different concentrations tested which were as follows: 500, 100, 50, 10 and 5og/ol. In conclusion, Ardisia and Cinnamomum extracts contained terpenoids that exhibited antibacterial properties. The terpenoids from the two different plant species were found to be active against MSSA, MRSA and B. subtilis bacteria. Moreover, the inhibitory activities exhibited against those gram-positive bacteria showed the potential emergence of a new drug.