Effects of high doses of aspirin on kidney of mice

• Main Author: Sia, Beverly S.
• Format: text
• Language: English
• Published: Animo Repository 1997
• Subjects: Aspirin; Kidneys; Mice
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/1468
• Institution: De La Salle University

Ten white male mice were treated with different concentrations of aspirin thrice a week for a duration of one month. The mice were divided into five groups, each with two replicates. After one month of administration, the kidneys were processed for slide preparations and the tissues were examined under the light microscope. The first group which served as the control was not treated with aspirin. The second group was administered with 100 mg/kg aspirin and showed enlarged and swollen glomerulus. The remaining groups were treated with 300 mg/kg, 500 mg/kg and 700 mg/kg aspirin respectively. Their glomeruli showed prominent capsular crescents on the epithelium lining the Bowman's capsule. The convoluted tubules of all the treated kidneys showed cellular swelling and granularity. Vacuolation or the accumulation of fat droplets was also prominent in the lumen of the convoluted tubules of all the treated kidneys. The accumulation of red blood cells on the peripheral areas of the convoluted tubules of the kidney treated with 700 mg/kg aspirin was also observed. The results of the experiment suggest that aspirin is toxic and can cause renal diseases when taken in large doses.