Investigative study on the oxacillin-resistance and cephalosporin-resistance among Staphylococcus aureus isolated from patients in Philippine General Hospital

• Main Author: Ang, Lesley Monica
• Format: text
• Language: English
• Published: Animo Repository 1998
• Subjects: Antibiotics > Testing; Drug resistance in micro-organisms; Microorganisms > Effect of drugs on
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/1558
• Institution: De La Salle University

Seventy-eight clinical isolates of Staphylococcus aureus were collected from patients of Philippine General Hospital and tested for their response against oxacillin, and three commonly prescribed Cephalosporins, cefotaxime, cefoperazone, ceflazidime using the Kirby-Baner disk agar diffusion method. Results showed fifty-four (54) of the total numbers of isolates or sixty-nine percent (69%) exhibited resistance to oxacillin and the cephalosporins, and twenty-four isolates or thirty-one percent (31%) inhibited all. However, nine isolates or 11.54% were reported as intermediate to some of the antibiotics tested. Chi-square test for independence was computed and result showed that the values from the antibiotics were not independent with each other. These data conformed to the statement made by National Committee on Clinical Laboratory Studies (NCCLS, 1996) that methicillin-resistance or oxacillin-resistance is an indicator of cephalosporin-resistance, which may be due to the fact that these antibiotics possess the same basic beta-lactam ring. Therefore the mechanism of resistance of Staphylococcus aureus to these antibiotics may be the same.