Analgesic property of Atalantia retusa Merr. (Rutaceae) non-polar extract on rats and mice
The continuous search for bioactive compounds capable of effectively inhibiting nociception has directed the study to investigate on the analgesic potential of Atalantia retusa. Male ICR mice (n=9) and Sprague-Dawley rats (n=6) were used to verify antinociception using the somatic and visceral pain...
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| Format: | text |
| Language: | English |
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Animo Repository
2008
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| Online Access: | https://animorepository.dlsu.edu.ph/etd_bachelors/2457 |
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| Institution: | De La Salle University |
| Language: | English |
| Summary: | The continuous search for bioactive compounds capable of effectively inhibiting nociception has directed the study to investigate on the analgesic potential of Atalantia retusa. Male ICR mice (n=9) and Sprague-Dawley rats (n=6) were used to verify antinociception using the somatic and visceral pain models respectively. There was significant (P < 0.001) inhibition of abdominal stretches in mice administered with the median dose (1.437mg/kg BW) of the non-polar extract, which is 55.48% better compared to the positive control (10mg/kg BW). Concomitantly, the non-polar extract have significantly (P < 0.05) inhibited paw licking and biting in the somatic model by 6.05% better compared to the positive control. The current study demonstrated the potential use of A. retusa as an analgesic drug. |
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