The effects of L-carnitine on the embryonic development of (Danio rerio) zebra fish
This study aimed to determine the effects of L-carnitine on rate of normal development and morphology of zebra fish embryos at different stages of its development. In this study, the only animal model used was the zebrafish (Danio rerio) and it was examined morphologically only, no biochemical or hi...
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| Format: | text |
| Language: | English |
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Animo Repository
2011
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| Online Access: | https://animorepository.dlsu.edu.ph/etd_bachelors/2478 |
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| Institution: | De La Salle University |
| Language: | English |
| Summary: | This study aimed to determine the effects of L-carnitine on rate of normal development and morphology of zebra fish embryos at different stages of its development. In this study, the only animal model used was the zebrafish (Danio rerio) and it was examined morphologically only, no biochemical or histological analysis of the embryos was conducted. L-carnitine is currently a popular nutrient supplement in several foods and drinks. It is claimed by the foods and beverages industry, as effective at inducing and maintaining weight loss. Its a nutrient that helps the body turn fat into energy and reduces unwanted toxins from the body. Also, is synthesized primarily by the liver and other tissues of the body playing an important role in energy production. Zebra Fish (Danio rerio) was determined as a wonderful model of studying vertebrate development and genetics by Dr. George Streisinger of University of Oregon year 1970s. And it is very popular worldwide as means of understanding how all vertebrates develop from the moment of fertilization. In this study, Zebra fish was used to test the effects of L-carnitine with different concentrations (control, 1.0mg/ml. 0.5mg/ml and 0.1mg/ml) in the embryological development of Zebra fishes. Results showed that L-carnitine at high dose (1.0 mg/ml) has a potential negative effect on normal embryonic development of Zebra fish up to 35 hours of development. Also, lower doses of L-carnitine (0.5mg/ml and o.1mg/ml) did not show any significant negative effect on the embryos. Therefore, results raised the possibility that excessive L-carnitine intake may potentially have detrimental effects on mammalian embryonic development such as in humans. The mechanisms of actions of such effects are unclear and warrant further study |
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