Effects of creatine monohydrate supplementation on creatinine clearance

• Main Authors: Vives, Mark Jeremy L., Landas, Jennie May S.
• Format: text
• Language: English
• Published: Animo Repository 1997
• Subjects: Creatinine; Biology
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/4028
• Institution: De La Salle University

Creatine supplementation promotes muscular growth, increases the storage of instant anaerobic energy, increases muscle strength, and improves endurance by delaying fatigue. This supplement is thus important in the world of fitness. The effects of creatine supplementation on the quantitative values of creatinine clearance was tested over a duration period of 2 weeks. This was also done to determine if such creatine supllementation caused abnormal amounts of excreted creatinine that would resuls in renal dysfunction. The experiment consisted of 25 randomly selected subjects. Screening of subjects was done, by choosing men between the ages of 18-25, involved in some form of physical activity at least three times a week, and current diet did not include the use of diuretic drugs, coffee/tea, or other supplement's. The subjects selected, were divided randomly into two groups of ten and a single group of five. The first group were subjected to creatine loading, which consisted of 6 creatine tablets for the first 3 days and one for every succeeding day. The second group was subjected to creatine maintenance, which consisted of 1 tablet a day. The final group of five, were subjected to a placebo. Each subject was required to collect a 24-hour urine sample, and have at least 5cc's of blood extracted. The experiment lasted for two weeks with testing of blood and urine before, midway, and after creatine supplementation. After each individual tests were completed, analysis and computations, were performed to express creatinine clearance values. Normal creatine values for men ranged from 95-156 ml/min. All subjects, with the exception of two, fell within the range. The creatinine clearance values were analyzed with the Standard Analysis of Variance test (ANOVA). This test showed that there was no significant change in creatinine clearance variance before, midway, or after creatine supplementation, nor in the different dosages of supplementation, being loading, maintenance, or placebo. Therefore the conclusion is that creatine supplementation has no effect on either creatinine clearance or cause abnormal levels of creatinine excretion.