Antibiotic response, conjugal transferability and curability of antibiotic resistance of Escherichia coli isolated from pregnant women with urinary tract infection

• Main Authors: Banagale, Ma. Ayesha, Castro, Jerome, Estrada, Mary Grace, Lopez, Gracielle, Sia, Gomelia
• Format: text
• Language: English
• Published: Animo Repository 1992
• Subjects: Antibiotics; Drug resistance in micro-organisms; Urinary tract infections; Micro-organisms, Effect of drugs on; Pregnant women
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/5915
• Institution: De La Salle University

Twenty-nine Escherichia coli isolates from pregnant women with urinary tract infection (UTI) were tested for their antibiotic sensitivity patterns using the disc agar diffusion method. The antibiotics used were ampicillin (10 ugs), amoxicillin (25 ugs), nalidixic acid (30 ugs) and nitrofurantoin (300 ugs), the most commonly prescribed antibiotics to pregnant women with UTI. Results showed that resistance to ampicillin and amoxicillin were more common than that to nalidixic acid and nitrofurantoin.The minimum inhibitory concentration (MIC) of the four antibiotics commonly prescribed to treat UTI cases were also determined. Results showed that isolates tested to be resistant to particular antibiotics using the disc agar diffusion method may be sensitive to the antibiotics in the urine level because the MIC of the antibiotics against the isolates were achievable in the urine level.Of the E. coli isolates tested for their conjugative transferability, seven transferred their resistance traits. Isolates tested showed conjugation frequency values that fall within the range characteristics of plasmid transfer.