Antibiotic resistance of Enterobacter aerogenes causing urinary tract infection and the effect of elevated temperature-incubation on the antibiotic resistance of the isolates

• Main Authors: Bautista, Filbert, Cleofas, Melvin, Tan, Sandy, Verzosa, Mario
• Format: text
• Language: English
• Published: Animo Repository 1993
• Subjects: Antibiotics; Urinary tract infections; Drug resistance in micro-organisms; Micro-organisms, Effect of temperature on
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/5917
• Institution: De La Salle University

Twenty Enterobacter aerogenes isolates from urinary tract infection cases from the Veterans Memorial Hospital and National Kidney Institute were tested for their response to commonly-used antibiotics. Using the modified kirby-Bauer disc agar-diffusion method of antibiotic sensitivity testing where the concentrations tested were based on the attainable peak plasma concentration, 85 percent were found to be resistant to ampicillin, 80 percent to chloramphenicol, 50 percent to ceftazidlime, 45 percent to kanamycin, 40 percent to gentamicin, 40 percent to cefotaxime, 15 percent to nalidixic acids, and 10 percent to amikacin. The minimum inhibitory concentrations of some of the test antibiotics showed that 27 percent were resistant to gentamicin, 13 percent to ampicillin, and none were resistant to ceftazidime based on the attainable peak urine concentration of the antibiotics. Incubation of the isolates at elevated temperature of 42 C resulted in the elimination of some of the antibiotic resistance of the isolates tested.