Secondary metabolites from Rosa sp. and Allamanda neriifolia Hook

• Main Author: Alimboyoguen, Agnes B.
• Format: text
• Language: English
• Published: Animo Repository 2007
• Subjects: Metabolites; Roses; Bacillus subtilis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etd_masteral/3572; https://animorepository.dlsu.edu.ph/context/etd_masteral/article/10410/viewcontent/CDTG004373_P.pdf
• Institution: De La Salle University

Two ornamental plants, Rosa sp.., commonly known as red rose and Allamanda neriifolia Hook., also known as yellow bell were studied for their chemical constituents. The air-dried flowers of Rosa sp. afforded 2- oxopomolic acid by silica gel chromatography. Its structure was elucidated by extensive 1D & 2D NMR spectroscopy. This is the first report on the complete NMR assignments of 2- oxopomolic acid. The 2-oxopomolic acid was tested for antimicrobial activity against seven microorganisms. Results of the study indicated that it was active against the fungi, Candida albicans and Trichophyton mentagrophytes with activity index of 0.3 and 0.2 respectively at a concentration of 30 g. It was also found to be slightly active against the bacteria, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus with activity index of 0.1, 0.2 and 0.1 respectively, at the same concentration. It was inactive against Bacillus subtilis and Asperigillus niger. The air-dried petals of Allamanda neriifolia Hook. afforded a new fatty alcohol cinnamate ester by silica gel chromatography. Its structure was elucidated by extensive 1D and 2D NMR spectroscopy. Mass spectroscopy indicated that this substance is composed of cinnamate and a mixture of saturated and unsaturated fatty alcohols with varying chain lengths.