Molecular detection and characterization of KRAS mutations among patients with colorectal adenocarcinoma in a tertiary hospital in Metro Manila

• Main Author: Nuylan, Michelle L.
• Format: text
• Language: English
• Published: Animo Repository 2009
• Subjects: Adenocarcinoma; Colon (Anatomy)—Cancer; Rectum—Cancer; Cancer; Mutation (Biology); Biology
• Online Access: https://animorepository.dlsu.edu.ph/etd_masteral/6455; https://animorepository.dlsu.edu.ph/context/etd_masteral/article/13134/viewcontent/CDTG004784_P.pdf
• Institution: De La Salle University

Activation of KRAS oncogene is responsible for the transition from intermediate adenoma to carcinoma in the colon. The gene is composed of 5 exons and encodes a 21kDa protein that acts as an intermediate molecule in signal transduction pathway by transferring information from the membrane to the nuc...