Ponatinib analogues: Virtual screening, precursor, synthesis, and approaches in the preparation of selected compounds
Ponatinib (AP24534), a chemotherapeutic agent used to treat chronic myeloid leukemia, exhibits its action through the competitive inhibition of BCR-ABL tyrosine kinases. Although it is potent enough to inhibit resistant variants of the enzyme including the T315I mutant, compound point mutations in t...
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| Format: | text |
| Language: | English |
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Animo Repository
2020
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| Online Access: | https://animorepository.dlsu.edu.ph/etd_masteral/6337 https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=13407&context=etd_masteral |
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| Institution: | De La Salle University |
| Language: | English |