Synthesis and characterization of novel pyrazinamide analogs of aspirin and salicylic acid

• Main Author: Lagua, Faith Marie G.
• Format: text
• Language: English
• Published: Animo Repository 2011
• Subjects: Pyrazinamide—Synthesis; Chemicals and Drugs; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etd_masteral/6913
• Institution: De La Salle University

Pyrazinamide (PZA) analogs of salicylic acid (Compounds 5a and 5b) and aspirin (Compounds 6a and 6b) were synthesized and characterized. The synthesis involved the preparation of salicylic acid and aspirin derivatives with varying acyl chains. The precursors were then coupled with 2-pyrazinehydrazide producing the desired PZA analogues. These compounds may exhibit increased potency against pyrazinamide-resistant and susceptible strains of Mycobacterium tuberculosis. [Hexagonal structure] NNNNHOROOHOH 5a R = -(CH2)6CH3 5b R = -(CH2)2CH3 NNNNHOROOHOO 6a R = -(CH2)6CH3 6b R = -(CH2)2CH3.