1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides

1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides

The 3' / 5'-OH and the 2'-OH/amino/imino functions of adenosine, cytidine and uridine were protected with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TIPDSiCl2) and 2,2,2-trichloro-tertiarybutylesterchloroformate (TCBOC-C1), respectively in two stages. Cleavage of the tetraisopropy...

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Main Author: Arnaez, Maria Luisa V.
Format: text
Language:English
Published: Animo Repository 1985
Subjects:
Ribonucleosides
Chemistry
Education
Online Access:https://animorepository.dlsu.edu.ph/etd_masteral/1121
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Institution: De La Salle University
Language: English
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spelling oai:animorepository.dlsu.edu.ph:etd_masteral-79592021-02-02T10:18:35Z 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides Arnaez, Maria Luisa V. The 3' / 5'-OH and the 2'-OH/amino/imino functions of adenosine, cytidine and uridine were protected with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TIPDSiCl2) and 2,2,2-trichloro-tertiarybutylesterchloroformate (TCBOC-C1), respectively in two stages. Cleavage of the tetraisopropyldisiloxyl group was attempted using hydronium and flouride ions. NMR analysis showed partial deblocking at the 5'-position. 1985-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/etd_masteral/1121 Master's Theses English Animo Repository Ribonucleosides Chemistry Education
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
language English
topic Ribonucleosides
Chemistry
Education
spellingShingle Ribonucleosides
Chemistry
Education
Arnaez, Maria Luisa V.
1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
description The 3' / 5'-OH and the 2'-OH/amino/imino functions of adenosine, cytidine and uridine were protected with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TIPDSiCl2) and 2,2,2-trichloro-tertiarybutylesterchloroformate (TCBOC-C1), respectively in two stages. Cleavage of the tetraisopropyldisiloxyl group was attempted using hydronium and flouride ions. NMR analysis showed partial deblocking at the 5'-position.
format text
author Arnaez, Maria Luisa V.
author_facet Arnaez, Maria Luisa V.
author_sort Arnaez, Maria Luisa V.
title 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
title_short 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
title_full 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
title_fullStr 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
title_full_unstemmed 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (TIPDSiCl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (TCBOC-C1) as protective groups of ribonucleosides
title_sort 1, 3-dichloro-1, 1, 3, 3-tetraisopropyldisiloxane (tipdsicl2) and 2, 2, 2,-trichloro-tertiarybutyl-esterchloroformate (tcboc-c1) as protective groups of ribonucleosides
publisher Animo Repository
publishDate 1985
url https://animorepository.dlsu.edu.ph/etd_masteral/1121
_version_ 1712574865357144064

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