Antifungal aromatic compounds from the chloroform extract of Peperomia pellucida (Linn.) H.B.K.

• Main Author: Bantas, Mariam Dumato
• Format: text
• Language: English
• Published: Animo Repository 1998
• Subjects: Aromatic compounds; Chloroform; Extracts; Medicinal plants; Plants > Composition; Microbial sensitivity tests; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etd_masteral/1889; https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=8727&context=etd_masteral
• Institution: De La Salle University

The chloroform extract of the air-dried leaves of Peperomia pellucida (Linn.) H.B.K. afforded dill-apiol (PP1), pachypophyllin (PP5) and aurantiamide acetate (PP6). The structures of the compounds PP1 and PP5 were elucidated by extensive 1D and 2D NMR Spectroscopy and Mass Spectrometry for compound PP5, while the structure of compoung PP6 was identified by comparison of its 1H NMR spectral data with those reported in the literature of aurantiamide acetate.The antimicrobial analysis conducted for dill-apiol and pachypophyllin using the agar cup method indicate that the two isolates are active against the fungus Trychophyton mentagrophytes with activity indexes (AI) of 0.4 and 2.6 at 40 ug, respectively. However, the two isolates are inactive against the organisms Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeroginosa, Candida albicans and Aspergilus niger. Aurantiamide acetate was not analyzed for its biological activity due to the limited amount of the isolate.