A meta-analysis on the therapeutic effects of silver nanoparticles on colitis-induced mouse models

• Main Author: Cheuk, Yuen Kun Chelsea
• Format: text
• Language: English
• Published: Animo Repository 2022
• Subjects: Colitis; Nanoparticles; Silver > Therapeutic use; Biology
• Online Access: https://animorepository.dlsu.edu.ph/etdb_bio/20; https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=1020&context=etdb_bio
• Institution: De La Salle University

Colitis is an immunologically mediated disease characterized by inflammation in the gut and currently affects over 6 million individuals worldwide. Silver nanoparticles have been introduced as a novel therapy for colitis due to its anti-inflammatory properties. However, current studies have yielded conflicting results regarding silver nanoparticles on colonic recovery. In line with this, this study aims to perform a meta-analysis to deliver a comprehensive conclusion on the efficacy of silver nanoparticles as treatment for colitis.A systematic literature search was conducted using databases, such as PubMed, Scopus, Google Scholar, and ScienceDirect. Data from eligible articles were analyzed using Review Manager 5.4.1 for generation of forest plots reporting the outcome measures of colon length, colon weight, myeloperoxidase (MPO) activity, disease activity index (DAI) score, and microscopic score. The mean differences were calculated and interpreted. Subgroup analysis was conducted for forest plots yielding high heterogeneity.A total of 5 journal articles were included. Results of the study showed that silver nanoparticles held significant therapeutic effect for all outcome measures, especially for colonic length which was the primary outcome of interest. It was found that the anti-inflammatory effects of silver nanoparticles were dependent on nanoparticle morphology and dosage. Results also showed that combination therapy of silver nanoparticles with known anti-inflammatory drugs, such as sulfasalazine and mesalamine, yielded greater therapeutic effects on the mouse models.This meta-analysis found that silver nanoparticles exhibit a significant therapeutic effect on colitis-induced mouse models. It is recommended that future studies proceed to clinical trials to evaluate the effect of silver nanoparticles on a human model.