Meta-analysis of the antihyperglycemic effect of different forms of coffee on Mus musculus and Rattus norvergicus induced with type II diabetes mellitus

• Main Authors: Maligat, Miguela C., Sarrate, Patricia Fe D.S.
• Format: text
• Language: English
• Published: Animo Repository 2024
• Subjects: Type 2 diabetes; Hyperglycemia; Coffee; Mice; Rattus norvegicus; Biology
• Online Access: https://animorepository.dlsu.edu.ph/etdb_bio/79
• Institution: De La Salle University

Diabetes is categorized into types 1 and 2. The former is autoimmune in nature in addition to being hereditary while the latter is acquired. Despite their variations in pathophysiology, insulin signaling as well as its utilization encompasses both types with hyperglycemia, in addition to raised blood glucose levels being a hallmark. With T2DM being the main focus of this study, aside from its aforementioned negative byproduct effects, it is also attributed to dysfunctions in the liver through non-alcoholic fatty liver disease, or complications in glomerular filtration in the kidney. While there are multiple oral antidiabetic medications in the market, plant-based antihyperglycemic as a form of management have also surged in popularity. Coffee has been identified to possess antioxidant and antiinflammatory properties through its polyphenols, alkaloids, and chlorogenic acids. This meta-analysis employed a PRISMA diagram coupled with inclusion and exclusion criteria to gather experimental studies employing coffee in its liquid, extract, and solid forms ability to lower hyperglycemia brought about by T2DM . A risk assessment led to 11 studies to be reviewed comprising 6 mouse models and 5 rat models. The results of the meta-analysis determined that extract coffee has the greatest antihyperglycemic effect followed by solid forms, then diluent in both animal models. In addition to this, the systematic review provided insights on the potential of coffee to protect against erratic hyperglycemic effects on both the liver and kidney. Keywords: type II diabetes, hyperglycemia, antihyperglycemic, coffee, Mus musculus (house mouse), Rattus norveigcus (brown rat)