In-silico characterization of GPx4 and mutant structures to investigate potential critical residues

• Main Author: Cervania, Cameron Niro
• Format: text
• Language: English
• Published: Animo Repository 2023
• Subjects: Enzymes—Regulation; Biochemistry, Biophysics, and Structural Biology
• Online Access: https://animorepository.dlsu.edu.ph/etdb_chem/32; https://animorepository.dlsu.edu.ph/context/etdb_chem/article/1037/viewcontent/2023_Cervania_In_silico_characterization_of_GPx4_and_mutant_structures_Full_text.pdf
• Institution: De La Salle University

Glutathione Peroxidase 4 (GPx4) is a critical enzyme for survival due it being the sole enzyme responsible for repairing oxidative damage that accumulates in the membrane. To this end, it has a number of structural features that allow it to accommodate a variety of substrates, as well as be potentia...