Predicting energetically favorable residue interactions between LL-37 and familial alzheimer's disease mutants of Aβ42 using molecular dynamics simulations

• Main Author: Miranda, Martin Carlos Y.
• Format: text
• Language: English
• Published: Animo Repository 2024
• Subjects: Alzheimer's disease; Amyloid beta-protein; Peptides; Molecular dynamics; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etdb_chem/48; https://animorepository.dlsu.edu.ph/context/etdb_chem/article/1056/viewcontent/2024_Miranda_Predicting_energetically_favorable_residue_interactions_between_L.pdf
• Institution: De La Salle University

Amyloid beta (Aβ) peptides self-aggregate into plaques, which is a hallmark of Alzheimer’s disease (AD) and is thought to cause the deterioration of neurons. Mutations at the E22 of the wildtype Aβ42 are likewise seen in patients with genetic and early-onset familial AD. It was previously shown that...