Degradation of trimethoprim (antibiotic) using uv-activated persulfate-based advanced oxidation and uv-activated sulfite- Based advanced reduction processes

• Main Author: Santillan, Hanna Shaira Y.
• Format: text
• Language: English
• Published: Animo Repository 2024
• Subjects: Persulfates; Sulfites; Trimethoprim; Antibiotics; Oxidation-reduction reaction; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etdm_chem/19; https://animorepository.dlsu.edu.ph/context/etdm_chem/article/1020/viewcontent/2024_Santillan_Degradation_of_Trimethoprim__Antibiotic__Using_UV_Activated_Persu_Full_text.pdf
• Institution: De La Salle University

The emerging global concern for the increasing concentration of antibiotics in wastewater poses a significant danger to developing antibiotic-resistant bacteria. Conventional treatment technologies could not eliminate trace amounts of these antibiotics in wastewater treatment. New methods were explored; among them, the Advanced Oxidation Process (AOP) and Advanced Reduction Process (ARP) showed great potential for efficient degradation of antibiotics. UV/Persulfate and UV/Sulfite systems were utilized in this study to measure their degradation efficiency relative to Trimethoprim. Optimization of parameters such as the initial pH of solution and PS or SF dosage was investigated using the Response Surface Methodology (Full Factorial Design). The optimum parameters generated by the model for the UV/PS system are at 0.994 mM PS and pH is 4, while the optimum parameters for the UV/SF system are 1.489 mM SF at pH 4. The predicted degradation efficiency was 103.56% for UV/PS and 42.99% for UV/SF system, whereas the actual efficiencies were 100% and 43.43%, respectively. Transformation products (TPs) were identified via LC-MS/MS, which revealed transformation pathways involving hydroxylation, oxidation and demethylation. The toxicological evaluation of the transformation products was evaluated using ECOSAR software, and it was estimated that four TPs from the UV/PS system may be harmful to Daphnia and green algae while the TP from UV/SF was found to have no toxicity on fish, Daphnia and green algae. Moreover, the presence of Ca2+ and CO32- ions can significantly inhibit the efficiency of the UV/SF system while no significant inhibition was observed in the UV/PS system.