Hypoglycemic effect of Musa acuminata aqueous leaf extract on alloxan-induced diabetic ICR mice (Mus musculus)

• Main Authors: Bascon, John Eduard R., Galvez, Tristan Josef E., Jabola, Kay T., Vitor, Rodel Jonathan S., II, Bueno, Paolo Robert P.
• Format: text
• Published: Animo Repository 2017
• Subjects: Musaceae—Physiological effect; Diabetes; Biochemistry; Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11601
• Institution: De La Salle University

Diabetes mellitus is a metabolic disease characterized by abnormally high glucose level in blood. Plant-based compounds are now being studied as alternatives for diabetes. Due to limited information on the pharmacologic activity of Musa acuminata, also known as “lakatan”, this study was carried out to determine the effect of Musa acuminata aqueous leaf extract on blood glucose level of alloxan-induced diabetes mice and to assess its safety in vivo. Thirty male ICR mice (Mus musculus) were divided into six groups (n=5) and were administered intraperitoneally with alloxan monohydrate (75 mg/kg) (5 groups), or normal saline solution (sham control group). Treatment groups were given distilled water (both sham and negative control groups), glimepiride (17.6 μg/kg, positive control), or one of the three doses of M. acuminata leaf aqueous extract tested (250, 500 and 1000 mg/kg) concomitantly via oral gavage for 28 days. The blood glucose levels of the mice were measured at baseline and at 0th, 14th and 28th. Phytochemicals present as well as signs of general toxicity were also determined. Results showed that M. acuminata (1000 mg/kg) significantly decreased blood glucose level (P