Functional and structural basis of E. coli enolase inhibition by SF2312: A mimic of the carbanion intermediate

• Main Authors: Krucinska, Jolanta, Lombardo, Michael N., Erlandsen, Heidi, Hazeen, Akram, Duay, Searle S., Pattis, Jason G., Robinson, Victoria L., May, Eric R., Wright, Dennis L.
• Format: text
• Published: Animo Repository 2019
• Subjects: Escherichia coli; Enolase; Metabolites; Carbanions; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11299
• Institution: De La Salle University

Many years ago, the natural secondary metabolite SF2312, produced by the actinomycete Micromonospora, was reported to display broad spectrum antibacterial properties against both Gram-positive and Gram-negative bacteria. Recent studies have revealed that SF2312, a natural phosphonic acid, functions...