Influence of starvation on heart contractility and corticosterone level in rats

• Main Authors: Lee, Sung Ryul, Ko, Tae Hee, Kim, Hyoung Kyu, Marquez, Jubert, Ko, Kyung Soo, Rhee, Byoung Doo, Han, Jin
• Format: text
• Published: Animo Repository 2015
• Subjects: Starvation—Physiological effect; Heart—Contraction; Cardiovascular System; Physiology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11527
• Institution: De La Salle University

The physiological changes, including cardiac modification, that occur during starvation are not yet completely understood. The purpose of this study is to examine the effects of a 2-week starvation period on heart contractility, muscle mass, and irisin and corticosterone levels in rats. Rats in the starved group showed a significant reduction in the body, heart, kidney, and muscle weight (n=23, p0.05). In the starvation group, the impairment of cardiac output was dependent on the reduction in stroke volume and heart rate. Starvation induced a severe reduction in ejection fraction and fractional shortening when compared with the body-weight-matched control group (p