Rescue of heart failure by mitochondrial recovery

Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an imp...

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Main Authors: Marquez, Jubert, Lee, Sung Ryul, Kim, Nari, Han, Jin
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Published: Animo Repository 2016
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Online Access:https://animorepository.dlsu.edu.ph/faculty_research/11529
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Institution: De La Salle University
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-117322024-03-18T02:23:17Z Rescue of heart failure by mitochondrial recovery Marquez, Jubert Lee, Sung Ryul Kim, Nari Han, Jin Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an important role in the progression of HF, and numerous studies have highlighted mitochondrial components that contribute to HF. This review presents an overview of the role of mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial permeability transition pore in HF, discusses ongoing studies that attempt to address the disease through mitochondrial targeting, and provides an insight on how these studies can affect future research on HF treatment. 2016-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/11529 info:doi/10.5213/inj.1632570.285, 2016 Faculty Research Work Animo Repository Mitochondria Heart failure Cardiovascular Diseases Systems and Integrative Physiology
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic Mitochondria
Heart failure
Cardiovascular Diseases
Systems and Integrative Physiology
spellingShingle Mitochondria
Heart failure
Cardiovascular Diseases
Systems and Integrative Physiology
Marquez, Jubert
Lee, Sung Ryul
Kim, Nari
Han, Jin
Rescue of heart failure by mitochondrial recovery
description Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an important role in the progression of HF, and numerous studies have highlighted mitochondrial components that contribute to HF. This review presents an overview of the role of mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial permeability transition pore in HF, discusses ongoing studies that attempt to address the disease through mitochondrial targeting, and provides an insight on how these studies can affect future research on HF treatment.
format text
author Marquez, Jubert
Lee, Sung Ryul
Kim, Nari
Han, Jin
author_facet Marquez, Jubert
Lee, Sung Ryul
Kim, Nari
Han, Jin
author_sort Marquez, Jubert
title Rescue of heart failure by mitochondrial recovery
title_short Rescue of heart failure by mitochondrial recovery
title_full Rescue of heart failure by mitochondrial recovery
title_fullStr Rescue of heart failure by mitochondrial recovery
title_full_unstemmed Rescue of heart failure by mitochondrial recovery
title_sort rescue of heart failure by mitochondrial recovery
publisher Animo Repository
publishDate 2016
url https://animorepository.dlsu.edu.ph/faculty_research/11529
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