The role of decorin in cardiovascular diseases: More than just a decoration

• Main Authors: Vua, Thu Thi, Marquez, Jubert, Le, Long Thanh, Nguyen, Anh Thi Tuyet, Kim, Hyoung Kyu, Han, Jin
• Format: text
• Published: Animo Repository 2018
• Subjects: Extracellular matrix proteins; Heart failure; Mitochondria; Physiology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11532
• Institution: De La Salle University

Decorin (DCN) is a proteoglycan constituent of the extracellular matrix (ECM) possessing powerful antifibrotic, anti-inflammation, antioxidant, and antiangiogenic properties. By attaching to receptors in the cell surface or to several ECM molecules, it regulates plenty of cellular functions, consequently influencing cell differentiation, proliferation, and apoptosis. These processes are dependent on cell types, biological contexts, and interfere with pathological processes such as cardiovascular diseases. In this review, we briefly discuss the potential of DCN targeting in addressing cardiovascular dis- eases (CVD). We dive into its interactome and discuss how its interaction with the proteins can affect disease progression, and how DCN can be a possible target for CVD therapeutics.