Understanding the hydrolysis and reactions of aminosugar Schiff base Pd(II) anticancer complexes: Dimerization and sugar displacement

• Main Authors: Alba, Laurenzo De Vera, Hatanaka, Tsubasa, Nakashima, Kazumichi, Funanashi, Yasuhiro
• Format: text
• Published: Animo Repository 2023
• Subjects: Antineoplastic agents; Amino sugars; Schiff bases; Hydrolysis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11482
• Institution: De La Salle University

Background: An anticancer and anti-metastatic aminosugar Schiff base Pd(II) complex (“Pd-Oqn”) was described previously1, and multiple variants have been synthesized. We noticed rapid changes in the UV-Vis spectra in buffered aqueous solutions at physiological pH, suggesting that the hydrolysis prod...