Pinpoint keV x-ray imaging for x-ray drug delivery system

• Main Authors: Uesaka, Mitsuru, Kuroda, R., Yamada, K., Mizuno, Kazue, Mori, A., Natsui, T., Taguchi, H., Trono, Jade Dungao
• Format: text
• Published: Animo Repository 2007
• Subjects: Drug delivery systems; X-rays; Diagnostic imaging; Atomic, Molecular and Optical Physics; Biological and Chemical Physics; Physical Sciences and Mathematics; Physics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/12846
• Institution: De La Salle University

In X-ray Drug Delivery System, anticancer drugs containing Pt, such as cisplatin and dachplatin, and Au colloid contrast agent are surrounded by polymers (micelle, PEG (polyethylene glycol), etc.). Ttheir sizes are controlled to be 20-100 nm. Since holes of capillary to organ are as large as 100 nm in only cancer, those large particles can be accumulated in cancer effectively. That is called as EPR (Extended Penetration and Retention effect). We have observed the distribution of Pt of dachplatin-micelle in cancer of mouse's pancreas by X-ray fluorescence analysis using 10 µm pinpoint 15 keV X-ray by Spring8. Further, in-vitro- and in-vivo-experiments of Au colloid PEG are under way. It is expected to be used as contrast agent for dynamic tracking treatment for moving cancer. Imaging properties for polychromatic X-rays from X-ray tube and monochromatic Compton source are numerically analyzed and discussed. We continue to analyze radiation enhancement by Auger electrons and successive characteristic X-rays and its toxic effect to cancer.