Human lung fibroblasts exhibit induced inflammation memory via increased IL6 gene expression and release

• Main Authors: Yap, Jennifer Maries Go, Ueda, Takashi, Kanemitsu, Yoshihiro, Takeda, Norihisa, Fukumitsu, Kensuke, Takehiro, Fukuda, Fukuda, Satoshi, Uemura, Takehiro, Tajihiri, Tomoko, Ohkubo, Hirotsugu, Maeno, Ken, Ito, Yutaka, Oguri, Testsuya, Ugawa, Shinya, Niimi, Akio
• Format: text
• Published: Animo Repository 2022
• Subjects: Fibroblasts; COVID-19 (Disease); Interleukin-6; Immunity; Respiratory Tract Diseases
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/13062
• Institution: De La Salle University

Fibroblasts of different origins are known to possess stromal memory after inflammatory episodes. However, there are no studies exploring human lung fibroblast memory which may predict a subsequent inflammatory response in chronic respiratory diseases and COVID-19. MRC-5 and HF19 human lung fibrobla...