Induction of innate immune responses by SIV in vivo and in vitro: Differential expression and function of RIG-I and MDA5

• Main Authors: Go, Juliene Kimberly G., Witner, Kenneth W., Gama, Lucio, Zink, M. Christine, Clements, Janice E.
• Format: text
• Published: Animo Repository 2011
• Subjects: Immune response; Simian immunodeficiency virus; Natural immunity; Immunology and Infectious Disease
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/13186
• Institution: De La Salle University

Interferon-β induction occurs during acute simian immunodeficiency virus (SIV) infection in the brain. We have examined expression and function of cytosolic RNA sensors, retinoic acid inducible gene I (RIG-I), and melanoma differentiation-associated protein 5 (MDA5), in vivo in the brain of our cons...