Interferon-α and -β restrict polyomavirus JC replication in primary human fetal glial cells: Implications for progressive multifocal leukoencephalopathy therapy

• Main Authors: Go, Juliene Kimberly G., Verma, Saguna, Gurjav, Ulziijargal, Sumibcay, Laarni, Nerurkar, Vivek R.
• Format: text
• Published: Animo Repository 2007
• Subjects: Interferon; Polyomaviruses; Neuroglia; Immunology and Infectious Disease
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/13185
• Institution: De La Salle University

One of the major limitations of highly active antiretroviral therapy is its inability to inhibit the replication of polyomavirus JC (JCV), the etiologic agent of progressive multifocal leukoencephalopathy (PML), an acquired immunodeficiency syndrome-defining illness. We previously demonstrated the i...