Preventive potential of cinnamon (Cinnamomum cassia) extract on aberrant crypt foci formation in the proximal and distal colon of azoxymethane-induced mice

• Main Authors: Sia, Aleli Jillian L., Ramos, Gliceria B., Legaspi, Carolyn Marie D., Tanchuco, John Edward O., de Vera, Minam P., Ples, Michael B., Sia Su, Glenn L.
• Format: text
• Published: Animo Repository 2013
• Subjects: Cinnamon—Therapeutic use; Cinnamon—Analysis
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1323; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2322/type/native/viewcontent
• Institution: De La Salle University

Cinnamon is known to contain primary polyphenols antioxidants that have the preventive potential against Aberrant Crypt Foci (ACF) formation and subsequent colon cancer development. This study aims to assess the preventive potential of Cinnamomum cassia extract on the development of ACF in mice colon. ICR male mice were divided into six groups: one positive control group (AOM only), three negative control groups (Saline only, Saline only+low dose and Saline only+high dose Cinnamon extract) and two treatment groups (AOM+low dose and AOM+high dose Cinnamon extract). On days 21 and 35, mice were sacrificed for colon extraction and subsequent histological analyses. Results revealed an increasing trend for mean ACF number, mean tumor number, crypt multiplicity and degree of dysplasia in Saline groups treated with low and high doses of Cinnamon indicative of prooxidant activity. A decreasing trend was found for AOM groups with low and high doses of Cinnamon extract indicative of its antioxidant activity. The low dose of Cinnamon showed prevention among mice sacrificed on day 21, whereas the high dose showed prevention on day 35 of tumor progression. The distal colon was found to be more susceptible to tumorogenesis than the proximal colon. Significant correlation was found between the day of sacrifice and mean tumor number, day of sacrifice and crypt multiplicity and day of sacrifice and moderate dysplasia revealing how preventive potential is related to phases of tumor development. Cinnamon was thus found to exhibit both antioxidant and prooxidant activities which are time and dose dependent. © 2013 Asian Network for Scientific Information.