Supercritical carbon dioxide-mediated hydrothermal extraction of bioactive compounds from Garcinia Mangostana pericarp

• Main Authors: Chhouk, Kimthet, Quitain, Armando T., Gaspillo, Pag Asa D., Maridable, Julius B., Sasaki, Mitsuru, Shimoyama, Yusuke, Goto, Motonobu
• Format: text
• Published: Animo Repository 2016
• Subjects: Mangosteen; Bioactive compounds; Chemical Engineering
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1590; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2589/type/native/viewcontent
• Institution: De La Salle University

Supercritical carbon dioxide in combination with hydrothermal process was used in the extraction of bioactive compounds from Garcinia mangostana pericarp. The extraction was carried out following pre-defined ranges of temperature (120-160 °C), pressure (5-15 MPa), extraction time (30-120 min), and particle size (0.3-0.9 mm), that served as parameters for determination of optimum yield. The extracts were subsequently analyzed for their total polyphenolic contents, antioxidant activity, and alpha-mangostin recovery. The multi-variable extraction process yielded several possible responses. Using response surface methodology (RSM) with central composite design (CCD), the optimal response obtained a yield of 39.9% w/w, with 22.0 gGAE/100 gextract of total polyphenolic contents, together with 73.2 μg/mL of antioxidant activity and 0.203% w/wextract recovery of alpha-mangostin. © 2015 Elsevier B.V. All rights reserved.