Hypoglycemic potential of triterpenes from alstonia scholaris

A dichloromethane extract of air-dry leaves of Alstonia scholaris (L.) R. Br. contains a mixture of cycloeucalenol (1a), cycloartanol (1b) and lupeol (1c); lupeol acetate (2); and betulin (3). The structures of these triterpenes were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed b...

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Main Authors: Ragasa, Consolacion Y., Lim, Kosta Fremmielle, Shen, Chien Chang, Raga, Dennis D.
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Published: Animo Repository 2015
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Online Access:https://animorepository.dlsu.edu.ph/faculty_research/1593
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-25922021-07-07T02:23:16Z Hypoglycemic potential of triterpenes from alstonia scholaris Ragasa, Consolacion Y. Lim, Kosta Fremmielle Shen, Chien Chang Raga, Dennis D. A dichloromethane extract of air-dry leaves of Alstonia scholaris (L.) R. Br. contains a mixture of cycloeucalenol (1a), cycloartanol (1b) and lupeol (1c); lupeol acetate (2); and betulin (3). The structures of these triterpenes were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed by comparison of their 13C NMR data to those reported in the literature. A previous study reported that the powdered leaves of Alstonia scholaris produced a highly significant decrease in blood glucose and a mechanism of this action was upon insulin triggering and direct insulin-like effects. Betulin and lupeol acetate were reported to exhibit hypoglycemic activity. Thus, only a mixture of 1a – 1c was tested for hypoglycemic potential using the oral glucose tolerance test (OGTT). A possible hypoglycemic activity was observed for a mixture of 1a – 1c at a dose of 25 mg/kg BW administered orally to normoglycemic mice. © 2015, Springer Science+Business Media New York. 2015-04-01T07:00:00Z text text/html https://animorepository.dlsu.edu.ph/faculty_research/1593 https://animorepository.dlsu.edu.ph/context/faculty_research/article/2592/type/native/viewcontent Faculty Research Work Animo Repository Apocynaceae Terpenes Betulin Chemistry
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic Apocynaceae
Terpenes
Betulin
Chemistry
spellingShingle Apocynaceae
Terpenes
Betulin
Chemistry
Ragasa, Consolacion Y.
Lim, Kosta Fremmielle
Shen, Chien Chang
Raga, Dennis D.
Hypoglycemic potential of triterpenes from alstonia scholaris
description A dichloromethane extract of air-dry leaves of Alstonia scholaris (L.) R. Br. contains a mixture of cycloeucalenol (1a), cycloartanol (1b) and lupeol (1c); lupeol acetate (2); and betulin (3). The structures of these triterpenes were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed by comparison of their 13C NMR data to those reported in the literature. A previous study reported that the powdered leaves of Alstonia scholaris produced a highly significant decrease in blood glucose and a mechanism of this action was upon insulin triggering and direct insulin-like effects. Betulin and lupeol acetate were reported to exhibit hypoglycemic activity. Thus, only a mixture of 1a – 1c was tested for hypoglycemic potential using the oral glucose tolerance test (OGTT). A possible hypoglycemic activity was observed for a mixture of 1a – 1c at a dose of 25 mg/kg BW administered orally to normoglycemic mice. © 2015, Springer Science+Business Media New York.
format text
author Ragasa, Consolacion Y.
Lim, Kosta Fremmielle
Shen, Chien Chang
Raga, Dennis D.
author_facet Ragasa, Consolacion Y.
Lim, Kosta Fremmielle
Shen, Chien Chang
Raga, Dennis D.
author_sort Ragasa, Consolacion Y.
title Hypoglycemic potential of triterpenes from alstonia scholaris
title_short Hypoglycemic potential of triterpenes from alstonia scholaris
title_full Hypoglycemic potential of triterpenes from alstonia scholaris
title_fullStr Hypoglycemic potential of triterpenes from alstonia scholaris
title_full_unstemmed Hypoglycemic potential of triterpenes from alstonia scholaris
title_sort hypoglycemic potential of triterpenes from alstonia scholaris
publisher Animo Repository
publishDate 2015
url https://animorepository.dlsu.edu.ph/faculty_research/1593
https://animorepository.dlsu.edu.ph/context/faculty_research/article/2592/type/native/viewcontent
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