Analgesic triterpenes from Ardisia cf. elliptica (subgenus: Tinus) (Myrsinaceae)

• Main Authors: Raga, Dennis D., Diezmos, Marie Luciene S., Orantia, Abigail Cheska C., Lo, Marvin James A., Evangelista, Juan Carlo P., Kim, Sang Hyeon, Shen, Chien Chang, Ragasa, Consolacion Y.
• Format: text
• Published: Animo Repository 2014
• Subjects: Myrsinaceae > Analysis; Phanerogams; Analgesics; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1649
• Institution: De La Salle University

The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and α-amyrin (1c). Their structures were identified by NMR spectroscopy. The mixtures of triterpenes (1a-1c) at ratios of 2:2:1 and 1:1:1 were tested for their analgesic property using the hot plate, tail flick and acetic acid-induced writhing assays. Results from the hot plate assay indicate that 5, 10, and 50 mg kg-1 body weight (BW) of 1a-1c (2:2:1) had analgesic activity comparable to the positive drug control (Diclofenac) at 75 min. Both ratios of 1a-1c were found not effective in the tail flick assay. The mixture (2:2:1) was found most effective in the acetic acid writhing assay. Reduced analgesic activity however was observed in the other mixture (1:1:1).