Synergy of in-situ formation of carbonic acid and supercritical CO2-expanded liquids: Application to extraction of andrographolide from Andrographis paniculata

• Main Authors: Rubi, Rugi Vicente C., Quitain, Armando T., Agutaya, Jonas Karl Christopher N., Doma, Bonifacio T., Soriano, Allan N., Auresenia, Joseph L., Kida, Tetsuya
• Format: text
• Published: Animo Repository 2019
• Subjects: Acanthaceae; Solvents; Solvent extraction; Chemical Engineering
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1709; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2708/type/native/viewcontent
• Institution: De La Salle University

The environmental impact of excessive solvent usage in the pharmaceutical industry has generated research interests in the area of green and sustainable extraction processes. In this study, solvent minimization was done by exploiting the synergistic effect of pH lowering (via in-situ H2CO3 formation...