Acetogenins from Annona muricata
Silica gel chromatography of the dichloromethane extract of the seeds of Annona muricata afforded annoreticuin-9-one (1), while the flesh of the fruit yielded cis-annoreticuin (2) and sabadelin (3). The structures of 1-3 were elucidated by extensive 1 D and 2D NMR spectroscopy and confirmed by mass...
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| Main Authors: | , , , , |
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| Format: | text |
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Animo Repository
2012
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| Online Access: | https://animorepository.dlsu.edu.ph/faculty_research/1739 https://animorepository.dlsu.edu.ph/context/faculty_research/article/2738/type/native/viewcontent |
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| Institution: | De La Salle University |
| Summary: | Silica gel chromatography of the dichloromethane extract of the seeds of Annona muricata afforded annoreticuin-9-one (1), while the flesh of the fruit yielded cis-annoreticuin (2) and sabadelin (3). The structures of 1-3 were elucidated by extensive 1 D and 2D NMR spectroscopy and confirmed by mass spectrometry. Acetogenins 1 and 2 were first isolated from A. reticulata and A. montana, respectively. Acetogenin 1 was reported to exhibit cytotoxic activities against the human pancreatic tumor cell line (PACA-2), human prostate adenocarcinoma (PC-3) and human lung carcinoma (A-549), while 2 was reported to exhibit cytotoxicity against human hepatoma carcinoma cell line (Hep G2). © 2012 Pharmacognosy Network Worldwide [Phcog.Net]. |
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