Cytotoxic and antimicrobial compounds from Cinnamomum cebuense Kosterm. (Lauraceae)

• Main Authors: Espineli, Dinah L., Agoo, Esperanza Maribel G., del Fierro, Ramon S., Shen, Chien Chang, Ragasa, Consolacion Y.
• Format: text
• Published: Animo Repository 2014
• Subjects: Cinnamomum > Analysis; Cinnamomum—Toxicity testing; Microbial sensitivity tests; Biology
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1788; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2787/type/native/viewcontent
• Institution: De La Salle University

The dichloromethane extract of Cinnamomum cebuense afforded α-terpineol (1), 4-allyl-2-methoxyphenol or eugenol (2), humulene (3), 4-hydroxy-3-methoxycinnamaldehyde (4) and a monoterpene (5) which were evaluated for cytotoxicity against colon carcinoma (HCT 116). Compound 4 showed moderate cytotoxicity against this cell line with an IC50 value of 18.8004 μg/mL, while 3 and 5 exhibited slight cytotoxicity. Compounds 3 – 5 were further tested for cytotoxicity against non-small cell lung adenocarcinoma (A549) and non-cancer Chinese hamster ovary cells (AA8). Sesquiterpene 3 exhibited moderate cytotoxicity against A549 with an IC50 value of 23.1964 μg/mL, 4 indicated slight cytotoxicity, while 5 was non-toxic against this cell line. Compound 4 showed moderate cytotoxicity against AA8 with an IC50 value of 20.4837 μg/mL, while 3 and 5 exhibited slight cytotoxicity. Compounds 1, 2 and 3 were active against bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis and fungi Candida albicans and Trichophyton mentagrophytes, but were found inactive against Aspergillus niger. Sesquiterpene 3 was the most active against E. coli, P. aeruginosa, S. aureus, C. albicans and T. mentagrophytes, while 1 exhibited the highest activity against B. subtilis, even surpassing the activity of the standard antibiotic chloramphenicol. © 2014, Springer Science+Business Media New York.