New triterpenes from Barringtonia asiatica

• Main Authors: Ragasa, Consolacion Y., Espineli, Dinah Lorenzana, Shen, Chien Chang
• Format: text
• Published: Animo Repository 2011
• Subjects: Lecythidaceae > Analysis; Anti-infective agents; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/1792; https://animorepository.dlsu.edu.ph/context/faculty_research/article/2791/type/native/viewcontent
• Institution: De La Salle University

The leaves of Barringtonia asiatica afforded two new triterpenes, germanicol caffeoyl ester (1) and camelliagenone (2). Their structures were elucidated by extensive 1D- and 2D-NMR spectroscopy. It also afforded germanicol trans-coumaroyl ester (3), germanicol cis-coumaroyl ester (4), germanicol (5), camelliagenin A (6), spinasterol, sitosterol, squalene, lutein and trilinolein. Compounds 3, spinasterol and trilinolein were isolated from the fruits, while the seeds yielded spinasterol, squalene, linoleic acid and trilinolein. Compounds 1-5 exhibited antifungal activity against Candida albicans, 1-3 and 5 showed antibacterial activity against Staphylococcus aureus, while 5 is active against Pseudomonas aeruginosa. © 2011 Pharmaceutical Society of Japan.