A bioactive sesquiterpene from Bixa orellana

• Main Authors: Raga, Dennis D., Espiritu, Rafael A., Shen, Chien Chang, Ragasa, Consolacion Y.
• Format: text
• Published: Animo Repository 2011
• Subjects: Annatto tree > Analysis; Bixaceae > Analysis; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/2328; https://animorepository.dlsu.edu.ph/context/faculty_research/article/3327/type/native/viewcontent
• Institution: De La Salle University

A dichloromethane extract of the air-dried leaves of Bixa orellana afforded ishwarane 1, phytol 2, polyprenol 3, and a mixture of stigmasterol 4a and sitosterol 4b by silica gel chromatography. The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy. Compound 1 at three doses (25,...