Structural properties of an S-system model of mycobacterium tuberculosis gene regulation

• Main Authors: Farinas, Honeylou F., Mendoza, Eduardo R., Lao, Angelyn R.
• Format: text
• Published: Animo Repository 2020
• Subjects: Mycobacterium tuberculosis; Gene regulatory networks; Chemical reactions; Mathematics; Medicine and Health Sciences
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/2616
• Institution: De La Salle University

Magombedze and Mulder (2013) studied the gene regulatory system of Mycobacterium tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the form of S-system, is represented by an embedded chemical reaction network (CRN), defined by a species subset and a reaction subset induced by the set of digraph vertices of the subsystem. For the embedded networks of S-system, we showed interesting structural properties and proved that all S-system CRNs (with at least two species) are discordant. Analyzing the subsystems as subnetworks, where arcs between vertices belonging to different subsystems are retained, we formed a digraph homomorphism from the corresponding subnetworks to the embedded networks. Lastly, we explored the modularity concept of CRN in the context of the digraph. © 2020, Department of Science and Technology. All rights reserved.